Leave San Francisco before 6:30am — ideally earlier — and you'll beat the worst of the Bay Bridge traffic and arrive in the valley before the parking lots seal shut and the shuttle lines form. The drive east on I-580 to I-205 to CA-120 is fast and flat through the Central Valley, the kind of honest agricultural driving that makes you appreciate what's coming: almond orchards and truck stops and the Sierra Nevada slowly materializing on the horizon as a white-tipped wall, growing bigger than seems possible the closer you get.
The better route, if you have the time, is CA-140 east from Merced — it adds a few minutes but rewards them. The road picks up the Merced River just past Mariposa and follows it through a narrowing canyon all the way into the park, the granite walls closing in from either side, the river going from wide and lazy to fast and white as you climb. You'll know you're close when the canyon starts to look like something that requires an explanation. Then the road curves, the valley opens, and El Capitan is simply there — three thousand feet of sheer granite filling the windshield — and you'll understand immediately why people have been pulling over and staring at this thing for a hundred and fifty years.
Stop at Tunnel View before you go anywhere else. Park, walk thirty feet to the overlook, and let it land: El Capitan on the left, Cathedral Rocks and Bridalveil Fall on the right, Half Dome floating in the middle distance. Photographers have been shooting this exact composition since 1865 and the view has not gotten worse. Give it twenty minutes.
For lodging, Yosemite Valley Lodge puts you close to the falls and the shuttle without requiring you to haul camping gear. If you want to tent it, Upper Pines Campground has sites along the Merced River — reserve these the moment the booking window opens, five months out to the day. If the valley is booked, the town of El Portal just outside the park has motels that will do. Walk to the Merced River before dinner and stand in it if the current isn't running too fast. The walls go 3,000 feet straight up on both sides. That's your welcome to the Sierra Nevada.
For dinner, the Ahwahnee Dining Room is formal, historic, and worth it for a splurge — book well ahead. The Village Grill Deck is dependable, unpretentious, and won't require a reservation. Eat early, get to bed, and set your alarm for 5:45am. Tomorrow is your first full day in the valley and you want to be on the trail before the shuttle lines form.